In Iran, the hydrogenated vegetable oil have a high content of trans fatty acids and high per capita consumption. This study was aimed to evaluate the effects of substitution of hydrogenated oil by sunflower liquid oil on plasma levels of LDL, HDL, total cholesterol and triglycerides in normal subjects. Thirty six healthy inmates participated in this research. They were consuming hydrogenated oil before the study, and were maintained on sunflower diet for one month. Then they were switched to hydrogenated oil regimen for the next two months. Blood samples were collected for measuring the levels of HDL-cholesterol, LDL-cholesterol, total cholesterol and triglycerids at the beginning and 15 days intervals during the study. The results showed that omission of hydrogenated oil from the diet significantly increases the serum HDL-cholesterol (P<0.001) level and reswitching from sunflower oil to shortening regimen reverts such beneficial effects. No significant difference was observed for the other measured parameters between the two lipid regimens.

Background and Aim: Sugar and Lipid disorders are the main risk factors for vascular abnormalities. Due to the gender and age, other variables can influence serum Fasting blood sugar and lipid levels, certifying the determination of population-specific reference interval. This study was designed to investigate the age-and gender-specific reference values for serum Fasting blood sugar (FBS), triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein-cholesterol (HDL) in healthy Babolian adults. Methods: FBS, TC, TG, and HDL were calculating applying the colorimetric method. The Friedewald equation (LDL=TC− HDL− TG/5) was used to calculate LDL concentrations in individuals. After using the exclusion parameters, 519 participants (199 men and 320 women) aged ≥ 23 years were included. The Clinical Chemistry guidelines of the International Federation applied for characterizing the reference values for samples. Results: Reference values for serum FBS, TG, TC, LDL, HDL were 77. 01-107. 69 mg/dL, 35. 34-204. 38 mg/dL, 117. 97-242. 81 mg/dL, 47. 6-137. 16 mg/dL and 33. 29-67. 13 mg/dL in men. In women, reference values for serum FBS, TG, TC, LDL, HDL were 75. 03-107. 99, 27. 49-192. 33 mg/dL, 125. 84-244. 32 mg/dL, 44. 08-139. 48 mg/dL and 36. 66-81. 1 mg/dL. FBS, TG, and LDL parameters were higher in men, and TC and HDL parameters were higher in women. Conclusion: Reference values for serum FBS, TC, TG, LDL, HDL in healthy Babolian adults were specified, and these data could supply a clear pathway for better decision making in both clinical settings and prevention.

Background: To study the association of plasma fibrinogen & total cholesterol levels, incidences, prevalence, and gender wise distribution in different etiologies of stroke. Methods: Fibrinogen & total cholesterol levels, prevalence, incidences, comorbidities, and different etiologies were assessed along with routine investigations and radiology inputs as per investigator’s discretion. The overall median values were represented in graphically format in MS-Excel. Results: 292 Males: 218 females. Age 30 to 80 years. Among, 25. 1% diabetic, 38. 9 % hypertension (HTN) and 31% diabetes + HTN. 5 % diabetes + HTN + dyslipidemia and other comorbidities. Overall, 73% had ischemic stroke (IS) & 27 % have hemorrhagic stroke (HS). Hemiparesis in 76. 5 %. Mean Fibrinogen elevated in 81% and range was 934±20 mg/dL. Total cholesterol level increased in 73. 2% & range was 365±10 mg/dL. The HS patients were experienced headache 77 (19. 60%) and vomiting 34 (24. 6%) than IS patients. As per radiological finding, the territory of Middle Cerebral Artery was the ordinary location of arterial territory infarctions in the IS form that was present in 213 (57. 2%) subjects following that in the anterior side of cerebral artery in 89 (23. 92%) and posterior cerebral artery was 44 (11. 82%). Arterial flutter found in 56 (10. 9%), Structural heart disease present in 30 (5. 88%), family history of stroke in 28 (5. 49%). Conclusion: Elevated fibrinogen & total cholesterol levels are independent significant primary biomarkers elevated with incidences of CV stroke. Stroke was higher in ischemic stroke group.